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Sildenafil Viagra - what is sildenafil used for General Information, sildenafil Viagra (in citrate form sold under the names Viagra, Revatio and under various other names, is a what is sildenafil used for drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH developed by the pharmaceutical company Pfizer. Its primary competitors on the market are tadalafil (Cialis and vardenafil (Levitra). Pharmacology of Sildenafil Viagra, sildenafil Viagra is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP leading to smooth muscle sildenafil citrate relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil Viagra is a potent and selective inhibitor sildenafil citrate of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil Viagra on board, normal sexual what is sildenafil used for stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil Viagra should not cause an erection. Sildenafil Viagra for patients, patient Information: Sildenafil should be used with caution in patients with anatomical deformation of the penis, sickle cell anemia, multiple myeloma, or leukemia. There is potential cardiac risk what is sildenafil used for of sexual activity in patients with preexisting cardiovascular risk factors. Patients should discontinue further sexual activity and contact the doctor if they experience chest pain, dizziness, or nausea upon initiation of the activity. Sildenafil may cause prolonged erections ( 4 hours) and priapism (painful erections greater than 6 hours in duration). If patients experience prolonged erections or priapism, they should contact their doctors immediately! Effects of Other Drugs on Sildenafil Citrate.
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